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Transformed DLBCL routinely add CDKN2A deletions and MYC translocations or amplifications on top of the genomic alterations currently existing in the first CLL, but absence the widespread mutations observed in Main DLBCL indicating they could correspond to a distinct biological class.eighty Richter transformation also takes place in sufferers taken care of with BTK inhibitors. These tumors tend not to typically obtain BTK or PLCG2 mutations but, if these were current in the first CLL, subclones may arise with added impartial mutations.89,90

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